inflammatory reaction
Conditions
Interventions
control group:normal saline
esketamine group:0.25mg/kg esketamine iv during general anesthesia induction
Sponsors
Xi'an International Medical Center Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 89 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients undergoing orthopedic surgery under general anesthesia. 2. Age range from 18 to 89 years old, regardless of gender. 3. ASA rating I - III.
Exclusion criteria
Exclusion criteria: Patients with cardiac, pulmonary, hepatic or renal insufficiency; patients with diseases of blood system; drug history including opioid analgesics, NSAIDs, antibiotics,steroid hormone and antidepressant one month before surgery; alcohol abuse history; having mental diseases; patients with endocrine related diseases such as thyroid disease, diabetes, and hypothalamic-pituitary-adrenal axis;infection within one month before surgery; having sedative, antiemetic or anti-Itch drugs 24 hours before operation; pregnancy or lactation; those unable to comprehend verbal instruction;the other factors may influence the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum IL-6 levels ;Incidence of adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum IL-1 levels;serum IL-10;The percentage of T lymphocyte subsets; The percentage of B lymphocyte;Whole blood counts;Cognitive function score; | — |
Countries
China
Contacts
Public ContactSiyuan Li
Xi'an International Medical Center Hospital
Outcome results
None listed