Schizophrenia
Conditions
Interventions
Patients with hyperprolactinemia:NA
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1) Each patient should be diagnosed as schizophrenia according to the DSM-IV-TR criteria; 2) Aged 18 to 45 years, han nationality, no gender limitation; 3) Biological parents are Chinese Han descents; 4) Patients with schizophrenia who received risperidone or paliperidone; 5) PRL > 50ng/ml; 6) Obtain the written informed consent of the patient, or the written informed consent of the legal guardian if the patient is incapacitated during the onset.
Exclusion criteria
Exclusion criteria: 1) Patients with the following DSM-5 diagnoses: organic mental disorders, depressive disorders, schizoaffective disorders, bipolar disorders, mental retardation, dementia, other cognitive disorders, alcohol and drug dependence, and Axis II disorders including personality disorders; 2) Those who are seriously suicidal or at risk of injuring others; 3) suffering from a serious or unstable physical disease; 4) Have a history of seizures; 5) Known pregnancy and/or breastfeeding, or planning pregnancy; 6) Participate in another clinical trial at the same time, unwilling or unable to complete the full course of the trial; 7) Patients with contraindications to risperidone, paliperidone and aripiprazole; 8) Diagnosis of pituitary tumor, hypothalamic disease, thyroid disease, primary or secondary amenorrhea.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| prolactin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive And Negative Syndrome Scale, PANSS;Clinical global impression, CGI; | — |
Countries
China
Contacts
Public ContactWeihua Yue
Peking University Sixth Hospital
Outcome results
None listed