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Organ protection effect of warm autogenous whole blood transfusion during off-pump coronary artery bypass grafting

Organ protection effect of warm autogenous whole blood transfusion during off-pump coronary artery bypass grafting

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300079141
Enrollment
Unknown
Registered
2023-12-26
Start date
2023-12-30
Completion date
Unknown
Last updated
2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary heart disease

Interventions

Experimental group:Warm autologous whole blood transfusion
Control group:Cell saver autologous blood recovery

Sponsors

Xiangya Hospital of Central South University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 85 Years

Inclusion criteria

Inclusion criteria: (i)Aged =65 years old;(ii)Patients plan to undergo selective off-pump off-cardiopulmonary bypass surgery;(iii)Patients voluntarily participate in the study and sign the informed consent.

Exclusion criteria

Exclusion criteria: (i)patients didn't sign the informed consent; (ii)participating in other clinical trails; (iii)impairments in thinking, speaking, hearing or communication; (iv)history of mental illness; (v)emergency operation; (vi)preoperative coagulation disorders or diseases of the blood system; (vii)severe abnormalities of liver and renal function (total bilirubin>102umol/L, glutamic pyruvic transaminase or glutamic oxalacetic transaminase>400u/L or serum creatinine>310umol/L, when a patient has one of the three, he is considered to have severe hepatic/renal insufficiency); (viii)fever with a body temperature above 38°C or systemic infection

Design outcomes

Primary

MeasureTime frame
Total perioperative transfusion units of non-erythrocyte allogeneic blood products;

Secondary

MeasureTime frame
Postoperative mechanical ventilation time;Postoperative oxygenation decreased incidence;Length of ICU stay;Postoperative hospital stay;Complication rate;Mortality rate;Systemic infections or allergies;Total hospital expenses;

Countries

China

Contacts

Public ContactLian Duan

Xiangya Hospital of Central South University

duanlian_ida@csu.edu.cn+86 135 4965 2849

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026