To compare the effects of alfentanil combined with different sedative drugs on the incidence of respiratory depression in patients with fiber colonoscopy under carbon dioxide partial pressure monitoring

To compare the effects of alfentanil combined with different sedative drugs on the incidence of respiratory depression in patients with fiber colonoscopy under carbon dioxide partial pressure monitoring - To compare the effects of different sedatives on respiratory depression under carbon dioxide partial pressure monitoring

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300079133

Enrollment

Unknown

Registered

2023-12-26

Start date

2024-01-01

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fiberoptic colonoscopy

Interventions

Remimazolam + cyclopofol anesthesia induction (RC) group:Under the monitoring of end-tidal carbon dioxide partial pressure, the anesthesia induction regimen of the RC group was designed as follows: al

Reimazolam + propofol anesthesia induction (RP) group:Under the monitoring of end-tidal carbon dioxide partial pressure, the anesthesia induction regimen of the RP group was designed as follows: alfen

Cyclopofol anesthesia induction (C) group:Under the monitoring of end-tidal carbon dioxide partial pressure, the anesthesia induction regimen of group C was designed as follows: alfentanil 10ug/kg and

Propofol anesthesia induction (P) group:Under the monitoring of end-tidal carbon dioxide partial pressure, the anesthesia induction regimen of group P was designed as follows: alfentanil 10ug/kg and p

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Gender is not limited;(2)Age 18~65 years old (including 18 years old and 65 years old); (3)BMI 18~28kg/m2;(4)ASA classification I~II.

Exclusion criteria

Exclusion criteria: (1) SpO2 =95% when inhaling air; (2) Non-invasive systolic blood pressure (SBP) = 90mmHg, non-invasive diastolic blood pressure (DBP) = 60mmHg; (3) Heart rate (HR) = 60 beats/min or =100 beats/min; (4) Allergies to eggs, soy products, opioids and their antidotes, propofol and other allergies; (5) Patients with contraindications to conventional endoscopic operation or refusal of sedation/anesthesia; (6) potentially life-threatening circulatory and respiratory diseases that are not properly controlled; (7) Infection, asthma attack, active epilepsy, etc.; (8) Liver dysfunction, acute upper gastrointestinal bleeding with shock, severe anemia, gastrointestinal obstruction with gastric content retention; (9) Those who are not accompanied or guardians; (10) Patients with obstructive sleep apnea syndrome (OSAS).

Design outcomes

Primary

Measure	Time frame
Duration of breath changes;	—

Secondary

Measure	Time frame
End-tidal carbon dioxide value;Respiratory rate;Pulse oximetry;Blood pressure;heart rate;	—

Countries

China

Contacts

Public ContactYang Haitao

The Second Affiliated Hospital of Dalian Medical University

yanghtdl@163.com+86 177 0987 1718

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026