brain function
Conditions
Interventions
Dexmedetomidine group:Firstly, a load dose of 0.6 µg/Kg within 10 minutes , then continuously dextrometomidine 0.5mg/kg/h and propofol 0.5mg/kg, then adjust the infusion rate of propofol to 0.5-3mg/kg
S-ketamine:Firstly, a loading dose of S-ketamine 1mg/Kg within 10 minutes, followed by continuously S-ketamine 0.5mg/Kg/h and propofol 0.5mg/Kg . Then adjust the infusion rate of propofol to 0.5-3mg/
control group:First, the same volume of normal saline as a placebo, then the load dose of propofol 0.5mg/Kg, and then adjust the infusion rate of propofol 0.5-3mg/Kg/h until consciousness disappears.
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Aged 60 and above healthy volunteers
Exclusion criteria
Exclusion criteria: 1) Refusal to participate ; 2) Previous history of neurosurgery surgery; 3) Intracranial tumors; 4) Clear history of ischemic or hemorrhagic stroke; 5) Neurological and psychiatric disorders, such as schizophrenia, depression, bipolar disorder, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain network connectivity strength; | — |
Secondary
| Measure | Time frame |
|---|---|
| MoCA score;Concentration of IL-6 and BDNF (brain derived neurotrophic factor); | — |
Countries
China
Contacts
Public ContactLi Chunjing
Peking University First Hospital
Outcome results
None listed