Pain
Conditions
Interventions
Bupivacaine liposome low concentration group:anterior serratus plane block by injection of 30 mL of liposomal bupivacaine (89mg)
Bupivacaine liposome medium concentration group:anterior serratus plane block by injection of 30 mL of liposomal bupivacaine (177mg)
Bupivacaine liposome high concentration group:anterior serratus plane block by injection of 30 mL of liposomal bupivacaine (266mg)
Ropivacaine group:anterior serratus plane block by injection of 30 mL of ropivacaine (75mg)
Lidocaine group:anterior serratus plane block by injection of 30 mL of lidocaine (300mg)
Sponsors
The First People's Hospital of Zhangjiagang
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: a. Aged 18-65 years and gender unlimited. b. Meet the diagnostic criteria for multiple rib fractures (may need to be confirmed by imaging). c. Pain VAS score =4 points. d. No serious cardiovascular, respiratory, liver and kidney function diseases. e. Agreed to receive bupivacaine liposomes for anterior serration plane block treatment, while not receiving other analgesic drugs, and voluntarily signed the patient's informed consent.
Exclusion criteria
Exclusion criteria: a. Hypersensitivity to local anesthetics or liposomes. b. Suffering from severe cardiovascular, respiratory, liver and kidney dysfunction. c. Use of other analgesics in the 24 hours prior to treatment. d. Have obvious mental illness or cognitive impairment. e. Pregnant or lactating female patients. f. Inability to cooperate with treatment or evaluation. g. There are other factors that may have influenced the results of the study, such as alcohol and drug abuse. h. Refusal to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain score ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of analgesia;Analgesic efficiency;Anxiety and depression scores;Spirometry;Recovery quality;Gastrointestinal motility and digestion;Post-blockade adverse reactions;Block implementation time; | — |
Countries
China
Contacts
Public ContactXu Zhenhua
The First People's Hospital of Zhangjiagang
Outcome results
None listed