type 1diabetes
Conditions
Interventions
Type 1 diabetes:None
Healthy control group:None
Sponsors
Department of Endocrinology, Lianyungang Clinical College of Nanjing Medical University/The First People’s Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
14 Years to 85 Years
Inclusion criteria
Inclusion criteria: Definite T1D requires that at least one of the following is present: 1) age less than 10 yr at diagnosis; 2) positive pancreatic autoantibodies at any time (GAD-65, IA-2, ICA, or ZnT8) or positive anti-insulin autoantibody at diagnosis only (within 10 d of starting insulin); or 3) the presence of two or more of the following clinical indicators suggestive of T1D: a) age at diagnosis less than 40 yr; b) nonobese at diagnosis according to body mass index (95th percentile pediatric and 30 kg/m2 adult); c) diabetic ketoacidosis (DKA) at any time; d) plasma C-peptide level below 0.8 ng/ml (with blood glucose 80 mg/dl if available) at any time; and e) family history of T1D in a first-degree relative (parent, sibling, or child).
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1) Type 2 diabetes patients, special type diabetes patients; 2) Patients with other autoimmune diseases or malignant tumors; 3) Patients with mental illness who cannot cooperate with this study; 4) Reject patients from this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rs2227981;sPD-1;RS2227982; | — |
Secondary
| Measure | Time frame |
|---|---|
| HbA1c;FPG;IAA;GADA;IA-2A;TC;TC;HDL;LDL;ALT;AST;UA;SCR; | — |
Countries
China
Contacts
Public ContactWang Guofeng
Department of Endocrinology, Lianyungang Clinical College of Nanjing Medical University/The First People’s Hos
Outcome results
None listed