Metabolic syndrome,bariatric surgery
Conditions
Interventions
Group H:Lidocaine at 1.5 mg/kg was given as a loading dose 10 minutes before induction, and maintained at 1.5 mg/(kg?h) after induction
Group M:Lidocaine at 1.0 mg/kg was given as a loading dose 10 minutes before induction, and maintained at 1.0 mg/(kg?h) after induction
Group L:Lidocaine at 0.5 mg/kg was given as a loading dose 10 minutes before induction, and maintained at 0.5 mg/(kg?h) after induction
Group N:Equal volume of normal saline is given for loading and maintenance
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age:18-65 years old; 2.BMI=30kg/m2; 3. Patients undergoing elective laparoscopic gastric volume reduction surgery; 4. ASA grade II-III; 5. Sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to amide drugs such as lidocaine; 2. Patients who need to be awake and intubated; 3. Patients with unsuccessful disposable endotracheal intubation; 4. Patients with bradycardia; 5. Patients with pheochromocytoma or hypertensive crisis; 6. Patients with severe cardiovascular diseases (such as myocardial infarction, heart failure, malignant arrhythmia, third-degree atrioventricular block, etc.); 7. Patients with hyperthyroidism and hyperthyroid crisis; 8. Patients who undergo bariatric surgery combined with other surgeries; 9. Patients who have been included in other interventional studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate variability; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamic changes;Perioperative opioid dosage;VAS score;Consumption of remedial analgesics within 24 hours;Postoperative nausea and vomiting grade;Consumption of salvage antiemetic medication within 24 hours;Incidence of intraoperative and postoperative adverse reactions to local anesthetics;Vasoactive drug usage rate; | — |
Countries
China
Contacts
Public ContactWang Guanglei
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed