Helicobacter pylori infection
Conditions
Interventions
metronidazole-containing bismuth quadruple therapy:NA
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Age = 18 years old, =70 years old. (2) H. pylori infection (Confirmed by a positive 13C breath test). (3) Consistent with H. pylori eradication certification (according to the Fifth National Consensus Report on the Management of Helicobacter pylori Infection). (4) Gastroscopy should be performed according to clinical needs. (5) Patients who had previously received H. pylori eradication eradication failed and were allowed to be enrolled after 3 months of discontinuation. (6) Metronidazole has not been used in the eradication of H. pylori.
Exclusion criteria
Exclusion criteria: (1) Taking metronidazole for other purposes (such as oral therapy, gynecology, etc.) for <7 days before treatment. (2) Previous gastric surgery. (3) Pregnant and lactating women. (4) History of PPI, bismuth or antibiotic use in the last 4 weeks. (5) Patients with severe liver, kidney, heart dysfunction, malignant tumor, cerebrovascular disease. (6) Patients who have received H. pylori eradication therapy within 3 months prior to treatment, or who have taken antibiotics in the month prior to treatment (recent use of antibiotics prior to treatment may affect the efficacy of H. pylori eradication). (7) Patients allergic to the drugs used in the eradication programme.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The best MIC cut-off point to predict the eradication outcome of amoxicillin + Metronidazole bismuth quadruple therapy; | — |
Secondary
| Measure | Time frame |
|---|---|
| rdxA gene mutation combination pattern that can predict the eradication outcome of amoxicillin + metronidazole bismuth quadruple therapy;Eradication rate of standard bismuth quadruple therapy containing metronidazole (1200mg/ day); | — |
Countries
China
Contacts
Public ContactSiyu Li
Beijing Hospital
Outcome results
None listed