hypertensive intracerebral hemorrhage
Conditions
Interventions
Intensive blood-pressure lowering group (Group A):Lowering systolic blood-pressure to 110-139 mmHg
Standard blood-pressure lowering group (Group B):Lowering systolic blood-pressure to 140-170 mmHg
Sponsors
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 78 Years
Inclusion criteria
Inclusion criteria: ? Patients agreed to participate and signed informed consent forms; ? Adult patients (range from 17 to 78 years old) with hypertensive intracerebral hemorrhage, who were admitted in 48 hours with systolic blood pressure >160mmHg; ? Patients with hypertensive intracerebral hemorrhage, who were underwent hematoma evacuation and ICP monitoring; ? Patients without postoperative hematoma expansion which demonstrated by CT scan; ? Patients with GCS 5-12.
Exclusion criteria
Exclusion criteria: ? Patients with traumatic brain injury, isolated intraventricular hemorrhage or systolic blood pressure <140mmHg; ? Patients with cerebrovascular diseases,such as aneurysm, vascular malformation, moyamoya disease, venous sinus thrombosis and so on; ? Patients with intracranial pathological changes including mental disorder, Parkinson's disease, cerebral infarction before hypertensive intracerebral hemorrhage; ? Patients with cerebellar hemorrhage, brain stem contusion, bilateral pupil dilation and GCS 3-4; ? Patients with known organ disorders, such as coronary heart disease, renal failure, liver dysfunction and need intervention by specialist; ? Patients taking anticoagulant therapies that could result in coagulopathies; ? Patients enrolled in other clinical trials in the last 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cerebral pressure reactivity index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean ICP;Mean CPP;Optimal CPP;The proportion of mean CPP in optimal CPP;GOS score at 3 months;GOS score at 6 months;mRS at 3 months;mRS at 6 months; | — |
Countries
China
Contacts
Public ContactFang Yuan
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed