intervertebral disc degeneration
Conditions
Interventions
Sponsors
The First Affiliated Hospital of University of South China
Eligibility
Sex/Gender
All
Age
6 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria of the control group : ( 1 ) no obvious degeneration of the intervertebral disc was confirmed by MRI before operation ; ( 2 ) The time from injury to operation was less than 72 h ; ( 3 ) No history of hormone use before injury ; ( 4 ) No history of chronic low back pain. 2.Inclusion criteria for the degeneration group : ( 1 ) Patients with typical IDD symptoms and signs, and confirmed by MRI ; ( 2 ) no history of lumbar hormone injection ; ( 3 ) No history of lumbar surgery.
Exclusion criteria
Exclusion criteria: Exclusion criteria for the control group and the degeneration group : ( 1 ) patients with spinal infectious diseases, such as intervertebral space infection, spinal tuberculosis, etc. ; ( 2 ) Complicated with spinal tumor ; ( 3 ) There is rheumatoid arthritis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RBM15; | — |
Secondary
| Measure | Time frame |
|---|---|
| NEK7;NLRP3;Overall m6A level;ASC;Caspase-1;IL-1ß;IL-18;GSDMD ; | — |
Countries
China
Contacts
Public ContactWei Yang
The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China
Outcome results
None listed