abortion
Conditions
Interventions
Normal pregnancy group:NA
RAS group:No processing
Sponsors
Dongguan Maternal and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. It conforms to the relevant diagnosis of RSA in the 2020 consensus of experts on the diagnosis and treatment of natural abortion in China, and has been clearly diagnosed through clinical and imaging examinations; 2. Have experienced more than one spontaneous abortion; 3. Good compliance; 4. Both spouses have normal chromosome karyotypes; 5. Age>18 years old,<35 years old; 6. Informed consent for this study.
Exclusion criteria
Exclusion criteria: 1. RSA caused by infection or immune related reasons; 2. People with autoimmune diseases, syphilis, AIDS, hepatitis B infectious diseases; 3. Patients with cervical dysfunction; 4. Non natural conception; 5. Severe lesions in important organs such as the heart, liver, and kidneys.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression levels of PTEN in blood, cells, and placenta;Expression levels of p-PI3K in blood, cells, and placenta;Expression levels of p-Akt in blood, cells, and placenta; | — |
Countries
China
Contacts
Public ContactHuang Lihua
Dongguan Maternal and Child Health Hospital
Outcome results
None listed