pediatric migraine
Conditions
Interventions
test group:Lactobacillus plantarum strain PS128+cyproheptadine
control group:Cyproheptadine
Sponsors
Qilu Hospital of Shandong university
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria. (1) Age 6-18 years, both sexes. (2) Meet ICHD-3 diagnostic criteria for migraine with aura, without aura, and chronic migraine. (3) Migraine diagnosed by two or more specialist neurologists. (4) PedMIDAS score = 11 (5) Migraine has never been treated. (6) Migraine attack characteristics are met: duration of illness >6 months; frequency of attacks >15 times/month; duration of each headache >4h; headache of moderate to severe severity. (7) Patients and family members have given informed consent to the study's purpose, significance, risks, benefits, and informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria. (1) presence of drug overdose (2) autoimmune diseases (3) neurological disorders other than migraine, intracranial masses (4) congenital or genetic disorders (5) diabetes, bronchial asthma, cardiovascular disease, pulmonary disease (6) other types of primary and secondary headache.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relief rates of pediatric migraine; | — |
Secondary
| Measure | Time frame |
|---|---|
| duration of migraine;VAS score of migraine;PACAP-38;CGRP;concomitant symptoms;aura symptoms; | — |
Countries
China
Contacts
Public ContactXinjie Liu
Qilu Hospital of Shandong University
Outcome results
None listed