percutaneous ultrasound-guided renal biopsy
Conditions
Interventions
intervention group:100 mL normal saline plus 500 mg vitamin C for 2 d(1 d before and after the biopsy), with intravenous administration
control group:100 mL normal saline for 2 d(1 d before and after the biopsy), with intravenous administration
Sponsors
Xijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.receiving written Informed Consent Form; 2.ranging from 18 years of age to 80; 3. accepting percutaneous ultrasound-guided renal biopsy; 4.blood pressure was lower than 140/90 mmHg with or without anti-hypertension therapy; 5.estimated glomerular filtration rate(eGFR) was equal or higher than 60 ml/min/1.73m²; 6.with normal coagulation function(PT>7.7s,INR>0.91s,APTT>26.6s,TT>14.5s,FIB>1.93s); 7.Plt>100*10^9/L ,Hb of males>70g/L(females>60g/L).
Exclusion criteria
Exclusion criteria: 1.patients with predisposition to allergies or history of adverse reaction from Vitamin C injection; 2.solitary kidney; 3.kidney cancer; 4.pregnant women; 5.patients with oliguria (urine volume<400ml/24h); 6.patients with diseases which could influence coagulation function such as thalassemia ,and cystinuria ,and glucose-6-phosphate dehydrogenase deficiency ,and etc. 7.Medications with nonsteroidal anti-inflammatory drugs(NSAIDs),antiplatelet agents or heparins were withdrawn before kidney biopsy ,eliminating interferences in hemostasis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| severe bleeding events;size of hematoma; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse drug reaction;other complications;Vital signs;physical examination;laboratory examination;ultrasonic examinations; | — |
Countries
China
Contacts
Public ContactHe, Lijie
Department of Nephrology, Xijing Hospital, The Fourth Military Medical University
Outcome results
None listed