liver transplantation
Conditions
Interventions
tranexamic acid group :After anesthesia induction, in the tranexamic acid group, tranexamic acid is infused at a rate of 10 mg/kg/h until opening of the portal vein
control group:In the control group, the normal saline is infused at the same way.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Adult patients =18 years old (2) Patients undergoing orthotopic liver transplantation under general anesthesia
Exclusion criteria
Exclusion criteria: (1) Acute arterial or venous embolism occurred within one month before surgery; (2) Patients with history of thrombophilia and Budd-Chiari Syndrome patients; (3) Patients with acute liver failure; (4) Patients undergoing retransplantation within one month; (5) Patients with renal disfunction requiring dialysis before operation; (6) Patients with epilepsy history; (7) Patients with a history of subarachnoid hemorrhage within one month before surgery or previous brain surgery; (8)Patients with allergy history to tranexamic acid, or have contraindications to tranexamic acid; (9) Refused to sign a consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of early allograft dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Thromboembolism incidence rate;Intraoperative blood loss and autologous blood recovery and infusion volume;Red blood cell infusion volume;The incidence of acute renal function injury;coagulation;Hospitalization duration and expenses;Other adverse events after surgery; | — |
Countries
China
Contacts
Public ContactYajie Zhang
Department of Anesthesiology, West China Hospital, Sichuan University
Outcome results
None listed