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Exploratory clinical trial of PET-MRI application of 64Cu-DDR2 compared to 18F-PDG in preoperative diagnostic accuracy of newly diagnosed glioblastoma

Exploratory clinical trial of PET-MRI application of 64Cu-DDR2 compared to 18F-PDG in preoperative diagnostic accuracy of newly diagnosed glioblastoma

Status
Active, not recruiting
Phases
Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300079016
Enrollment
Unknown
Registered
2023-12-22
Start date
2024-01-01
Completion date
Unknown
Last updated
2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glioblastoma

Interventions

Gold Standard:pathological diagnosis
Index test:The accuracy of the diagnosis of the two tracers compared with the pathological diagnosis

Sponsors

Tangdu Hospital,Fourth Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. The participants of this study voluntarily enrolled, signed an informed consent form, and had good compliance; 2. Age: 18-75 years old (when signing the informed consent form), regardless of gender; ECOG score: 0-2 points (KPS score = 60 points); 3. Glioblastoma was considered through head MRI examination; 4. Female participants of childbearing age should agree to use contraceptive measures (such as intrauterine devices, contraceptives, or condoms) during the study period and within 3 months after the end of the study; Within 7 days prior to enrollment, the serum pregnancy test was negative and must be a non lactating subject; Male participants should agree to use contraceptive measures during the study period and within 6 months after the end of the study period; 5. The participants are able to metabolize the tracer normally; 6. The participants compliance is good.

Exclusion criteria

Exclusion criteria: 1. The participants has previously received any treatment for gliomas; 2. The participants who cannot undergo MRI examination; 3. The participants cannot accept surgical treatment aimed at large-scale resection of the lesion; 4. Diffuse meningeal dissemination evident on imaging; 5. The subject cannot lie flat for half an hour; 6. The participants with claustrophobia or other mental illnesses; 7. According to the researcher's judgment, there are accompanying diseases that seriously endanger the safety of the subjects or affect the completion of the study, or subjects who are deemed unsuitable for enrollment due to other reasons;

Design outcomes

Primary

MeasureTime frame
Accuracy of diagnosis;

Countries

China

Contacts

Public ContactLiang Wang

Tangdu Hospital,Fourth Military Medical University

doctorwangliang@163.com+86 133 1923 2049

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026