Alzheimer's disease
Conditions
Interventions
Group AD intervention:On the basis of maintaining Alzheimer's disease related medication, take composite probiotic capsules.
Group AD control:Maintain medication related to Alzheimer's disease and not take composite probiotic capsules.
Group MCI intervention:On the basis of maintaining Alzheimer's disease related medication, take composite probiotic capsules.
Group MCI control:Maintain medication related to cognitive impairment and not take composite probiotic capsules.
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: ?Age is =60 years old. ?Fulfilled National Institute on Aging Alzheimer’s Association criteria in 2011 for Probable AD dementia, or the modified MCI criteria in 2003: ?Patients with ß-amyloid (Aß) positive on positron emission tomography (PET) imaging or Aß and p-tau biomarkers positive in cerebrospinal fluid are prioritized for inclusion.
Exclusion criteria
Exclusion criteria: ? Cognitive impairment is caused by other neurological diseases or other causes such as syphilis and alcoholic encephalopathy etc. ? Patients with poor compliance, bad physical condition, and low educational level who cannot complete the whole examination. ? Other situations that the researchers believe may interfere with this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination, MMSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| Alzheimer's disease assessment scale, ADAS-cog;MoCA;ADCS-ADL;Changes in fecal metagenomic sequencing results; | — |
Countries
China
Contacts
Public ContactPeng Dantao
China-Japan Friendship Hospital
Outcome results
None listed