Painless bronchoscopy diagnosis and treatment
Conditions
Interventions
Dexmedetomidine + fentanyl group:Atomization inhalation of dexmedetomidine combined with fentanyl+ Lidocaine aerosol inhalation
Dexmedetomidine + esketamine group:Dexmedetomidine combined with esketamine aerosol inhalation+ Lidocaine aerosol inhalation
Dexmedetomidine group:Atomization inhalation of dexmedetomidine+ Lidocaine aerosol inhalation
placebo group:Lidocaine aerosol inhalation
Sponsors
First Affiliated Hospital of Gannan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I-III ; 2.Patients aged 18-80 years old, regardless of gender and race, were scheduled for painless fiberoptic bronchoscopy ; 3.The diagnosis and treatment time is less than 1 hour; 4. Voluntary subjects, signed informed consent, in line with medical ethics;
Exclusion criteria
Exclusion criteria: 1. Drug, alcohol and substance abusers ; 2. patients who had used psychotropic drugs or participated in clinical studies of other drugs within 3 months before enrollment ; 3. Bmi > 30Kg / M2; 4. Patients with liver and kidney dysfunction or recent active hepatitis ; 5. Patients with a history of allergies to the drugs used in the study ; 6. Pregnancy, lactation and short-term pregnancy plan ; 7. Patients with estimated intraoperative blood loss greater than 20 % of the total ; 8. Controlled hypotension during operation ; 9. severe dehydration and severe malnutrition ; 10. the presence of any nasal lesions or nasal congenital abnormalities ; 11. Those without autonomy, mental disorders or other reasons do not cooperate ; 12. patients with severe diseases such as heart, brain, blood system and malignant tumors ;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bronchoscopic sedation comprehensive score;Alertness / sedation score;Incidence and frequency of adverse reactions;Postoperative evaluation of medical staff and patients;Preoperative and postoperative hospital anxiety and depression scale;Preoperative and postoperative sore throat score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure saturation;Heart rate;Mean arterial pressure;Respiratory rate;The total amount of lidocaine and propofol and the use of remedial drugs were used;Time of diagnosis, treatment, awakening and leaving the room; | — |
Countries
China
Contacts
Public ContactChen Li
First Affiliated Hospital of Gannan Medical College
Outcome results
None listed