Atherosclerosis
Conditions
Interventions
Drug intervention group:oral terazosin hydrochloride tablets(0.5mg once a night)
Exercise intervention group:150 minutes of moderate exercise per week
Sponsors
Xijing Hospital, the First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: ? Over 40 years old, under 75 years old; ? Abnormal increase of baPWV, exceeding the normal reference value (1400cm/s) ? Control stable coronary heart disease, hypertension, no obvious sequelae of past stroke patients. ? Normal or mildly abnormal liver and kidney function ? no blood system diseases; ? Meets the following criteria: a. Self-care or basically self-care; b. Cognitive function is basically normal ? Sign informed consent.
Exclusion criteria
Exclusion criteria: ? People who have taken terazosin in the past three months or are allergic to it; ? Have taken Tamsulosin sustained-release capsules in the past three months; ? Patients hospitalized in the past 3 months due to major cardiovascular and cerebrovascular events, including myocardial infarction, angina pectoris, stroke, and arterial revascularization; ? Patients with heart failure and heart function below Grade II; ? Patients with malignant tumors; ? Can not cooperate with treatment and follow-up; ?Participating in other clinical trials; ? Inability to tolerate investigational drugs; ? Pregnant or lactating women; ? Those that researchers believe should not be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brachial-ankle pulse wave velocity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Carotid intima-media thickness;Circulating inflammatory factor;blood lipid; | — |
Countries
China
Contacts
Public ContactWang Xiaoming
Xijing Hospital, the First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed