Colorectal cancer
Conditions
Interventions
Esketamine group:Esketamine 0.1mg/kg was slowly pushed before incision, and then esketamine 0.12mg·kg-1·h-1 was continuously pumped intravenically until the end of surgery
Lidocaine group:Lidocaine was given 2 mg/kg slow infusion before incision, followed by lidocaine 1.5 mg·kg-1·h-1 continuous intravenous pump until the end of surgery
Lidocaine and Esketamine group:Before incision, lidocaine 2mg /kg+ esketamine 0.1mg/kg was slowly injected, and then lidocaine 1.5 mg·kg-1·h-1 and esketamine 0.12mg·kg-1·h-1 were continuously pumped i
Control group:The same amount of normal saline was given before and during the operation
Sponsors
Xiangyang Central Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: Age =60 years old; ASA Grade I - III; Laparoscopic radical resection of colorectal cancer under quasi-general anesthesia; No previous history of allergy to narcotic drugs; Sign the informed consent form.
Exclusion criteria
Exclusion criteria: Previous history of neuropsychiatric diseases such as cerebrovascular disease, Parkinson's disease, Alzheimer's disease, schizophrenia, etc. Currently using sedatives or antidepressants, etc.; Severe heart block or grade ? to ? heart function, uncontrolled hypertension, abnormal liver and kidney function; History of emergency surgery for colorectal cancer obstruction or perforation; Tumor invasion of adjacent vital tissues and organs; Obesity, extensive intraperitoneal adhesion, coagulation dysfunction; Preoperative cognitive dysfunction; Those who cannot cooperate to complete the cognitive function test; Persons with contraindications to esketamine and/or lidocaine; Other conditions determined by the investigator to be inappropriate for participation in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain score;Ramsay calm score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Opioid consumption;Length of stay; | — |
Countries
China
Contacts
Public ContactLiwen Zhou
Xiangyang Central Hospital
Outcome results
None listed