Helicobacter pylori infection
Conditions
Interventions
No pretreatment with proton pump inhibitors and vonorazen fumarate (control):Amoxicillin-vonoprazan dual therapy
Proton pump inhibitor pretreatment time is less than one week:Amoxicillin-vonoprazan dual therapy
Proton pump inhibitor pretreatment time is more than or equal to one week:Amoxicillin-vonoprazan dual therapy
vonoprazan pretreatment time is less than one week:Amoxicillin-vonoprazan dual therapy
vonoprazan pretreatment time is more than or equal to one week:Amoxicillin-vonoprazan dual therapy
Sponsors
Changzhou Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1: Age 18~70 years old, male or female 2: No antibiotics, bismuth, or H2 receptor antagonists used in the past four weeks, History of PPI or P-CAB applications; 3: 13C urea breath test positive or gastroscopy confirmed Helicobacter pylori infection 4: Have indications for Helicobacter pylori eradication treatment, and be willing to cooperate with doctors to conduct follow-up investigation of eradication efficacy.
Exclusion criteria
Exclusion criteria: 1: Severe heart, liver and kidney function damage 2: Pregnant or lactating women 3: Previous history of H. pylori therapy,History of upper gastrointestinal surgery, history of gastric malignancy, history of liver and kidney damage, history of pyloric stenosis, pregnancy. 4: Participation in other drug studies within 3 months ; 5: Taking non-steroidal anti-inflammatory drugs or alcohol abuse 6: Patients who are allergic to either drug of the dual regimen
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction; | — |
Countries
Chinese
Contacts
Public ContactXiaoyong Wang
Changzhou Second People's Hospital
Outcome results
None listed