AIDS with cryptococcal meningitis
Conditions
Interventions
Cryptococcal meningitis routine treatment group:?Antifungal: According to the Chinese AIDS Diagnosis and Treatment Guidelines (2021 Edition), the induction period of amphotericin B was 0.5-0.7 mg/ (kg
?Continuous external drainage in the lumbocisternia was performed, and amphotericin B combined with dexamethasone was used for intrathecal injection. The specific regimen was AmB 0.1-1.0mg plus dexame
Cryptococcal meningitis intrathecal injection group:In the intervention group, amphotericin (AmB) was added intrathecal injection on top of basic antifungal therapy. Amphotericin B combined with dexam
Sponsors
Chest Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Central nervous system symptoms, These included elevated intracranial pressure (headache, vomiting, papilledema), cerebral hernia (bilateral dilated pupils, changes in respiratory rhythm, disturbance of consciousness, etc.), positive meningeal stimulation (Kernig, Brudzinski), and pathological reflex (Babinski, Chaddoc) Symptoms of brain parenchymal damage (paralysis, including monoplegia, hemiplegia, cross paralysis or chronic paralysis, convulsions, tremors, dance-like movements, etc.), symptoms of brain nerve damage (diplopia, facial paralysis, vision loss, etc.), symptoms of spinal cord damage (radicular pain, sensory and motor impairments below the damaged plane, etc.Cauda equina nerve injury, urinary retention or incontinence, constipation or incontinence, etc.), GCS score of more than 8 points; (2) High cranial pressure (>200 mmH2O); (3) Cerebrospinal fluid biochemical and routine abnormalities, positive cerebrospinal fluid etiology evidence, or skull imaging support
Exclusion criteria
Exclusion criteria: (1) The diagnosis is not clear (2) The condition is more serious (3) Refusal to sign informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebrospinal fluid cryptococcus detection;Cerebrospinal fluid cryptococcus count;Amphotericin concentration in cerebrospinal fluid;Vital sign; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intracranial pressure; | — |
Countries
China
Contacts
Public ContactShanfang Qin
Chest Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed