Upper Tract Urothelial Carcinoma
Conditions
Interventions
Sponsors
The Second Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Clinical diagnosis of surgically resectable primary upper tract urothelial carcinoma (UTUC); 2.Able to provide written informed consent, comprehend, and agree to comply with study requirements; 3.Males or females aged over 18 years; 4.Treatment-naive patients who have not previously undergone any therapy and agree to receive treatment; 5.Underwent CT examination within 1 month prior, showing no evidence of significant metastasis; 6.Patients must be able to provide fresh tumor tissue (tumor tissue specimen 50mg/needle, using 18G needles for 2 punctures) along with its pathological report; 7.ECOG performance status of =1; 8.Patients must have at least one measurable lesion (evaluated according to RECIST v1.1); 9.Patients must have adequate organ function, with laboratory test values within normal ranges or meeting specified criteria within 7 days before treatment.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of other malignant tumors within the last 5 years, except for basal cell carcinoma, squamous cell carcinoma of the skin, or in situ cervical cancer, who have received potentially curative treatment and have not experienced a relapse within 5 years before the start of treatment, are eligible for the study. 2.Subjects who have received any approved antitumor therapy before starting the study treatment. 3.Severe chronic or active infections requiring systemic antibacterial, antifungal, or antiviral treatment, including pulmonary tuberculosis infection, etc. 4.Known human immunodeficiency virus infection. 5.Prior allogeneic stem cell transplantation or organ transplantation. 6.The investigator judges that the patient's compliance during the study period is inadequate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DFS; | — |
Countries
China
Contacts
Public ContactWang Liang
The Second Hospital of Dalian Medical University
Outcome results
None listed