Knee osteoarthritis
Conditions
Interventions
Test group:Heng-Gu-Gu-Shang-Yu-He-Ji+Gukang Capsule Simulator
control group:Heng-Gu-Gu-Shang-Yu-He-Ji Simulator+Gukang Capsules
Sponsors
The Third Affiliated Hospital of Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. In accordance with the western medical diagnosis of knee osteoarthritis, K&L grade 2-3; 2. In accordance with the TCM syndrome differentiation standard of liver and kidney deficiency combined with blood stasis syndrome; 3. Age 50-75 years old; 4.4 = VAS pain score =7; 5. Those who agree to participate in this clinical study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Tuberculosis, bone tumor or other diseases affecting the knee joints, such as rheumatoid arthritis, rheumatoid arthritis, psoriasis, metabolic bone disease, syphilitic neuropathy, ochronosis, acute trauma of the knee joints; (2) Patients received intra-articular treatment within 3 months before screening, including intra-articular injection, intra-articular irrigation, and arthroscopic surgery; Patients who used non-steroidal anti-inflammatory drugs, benzothiazides, glucosamine, chondroitin sulfate, or other drugs for the treatment of knee osteoarthritis and related traditional Chinese medicine within 1 week before screening; (3) patients with life-threatening diseases of the heart, brain, liver, kidney and blood system, including ALT, AST > 1.5 times the upper limit of normal, Scr > the upper limit of normal; Patients with digestive tract ulcer and glaucoma; 4. Allergy to celecoxib capsules or sulfonamides; 5. Pregnant and lactating women; 6. Patients who participated in other clinical trials within three months prior to screening; 7. Persons who were deemed by the investigators to be ineligible for the trial.(YNMT)·
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale (VAS) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee osteoarthritis/main symptoms and signs of traditional Chinese medicine syndrome classification of quantitative score worse than baseline values(YNMT)· ;Difference of WOMAC total score from baseline;WOMAC pain/stiffness/joint mobility score difference from baseline; | — |
Countries
China
Contacts
Public ContactChen Weiheng
The Third Affiliated Hospital of Beijing University of Chinese Medicine
Outcome results
None listed