Acute respiratory distress syndrome/Severe pneumonia
Conditions
Interventions
Continuous feeding:Enteral feeding is continuous via enteral nutrition pump during prone ventilation for 16 hours.
Cyclic feeding:During prone ventilation for 16 hours, enteral nutrition was continuously fed through the enteral nutrition pump for 14 hours, and bowel rest was given for 2 hours.
Intermittent feeding:During the prone ventilation for 16h, enteral nutrition was given in five times, each lasting 25~90min.
Sponsors
Gansu Provincial People‘s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Patient's age? 18 years old; (2) patients with moderate/severe ARDS (intubated patients with oxygenation index (PaO2/FiO2) ? 150 mmHg, positive end-of-respiratory pressure (PEEP) ? 5 mmHg) were included according to the new definition criteria for ARDS in 2023 [84], and patients with severe pneumonia intubated according to the Diagnostic Criteria for Severe Pneumonia Ninth Edition [85]; (3) PPV diagnosed by a doctor, the estimated ventilation time ? 3 days (72h), and the time of each PPV ?16h; (4) During PPV, enteral nutrition support was provided through a nasogastric tube, and the duration was ? 3 days; (5) The patient is analgesic and sedative, with a COPT score of less than 3 points and a RASS score of -3~-5 points.
Exclusion criteria
Exclusion criteria: (1) Patients aged ? 80 years; (2) Patients who need PPV after drowning, pregnancy, heart surgery, lung surgery, brain surgery, and digestive system surgery; (3) Patients with peptic ulcer, duodenal ulcer, gastrointestinal malignant tumor, and severe cardiohepatic and renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| High gastric residual volume, HGR;Indicators related to nutritional metabolism: albumin, globulin, prealbumin, hemoglobin, and urea nitrogen; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of vomiting and reflux;Incidence of aspiration pneumonia;Incidence of gastric bleeding;Daily feed ratio;Glycemic coefficient of variation; ICU mechanical ventilation time;Number of days in ICU;ICU mortality; | — |
Countries
China
Contacts
Public ContactLan Xuhong
Gansu Provincial People‘s Hospital
Outcome results
None listed