Obesity
Conditions
Interventions
Control:Oral administration of a placebo control
Li05:Oral administration of Pediococcus pentosaceus Li05
Sponsors
Shulan (Hangzhou) Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) Participants of any gender, within the age of 18 and 45 year-old (2) Body mass index (BMI) ) = 28 kg/m2 ; (3) Male waist circumference = 90 cm, female waist circumference= 80 cm; (4) Participants who have not used any antibiotics, probiotics, other intestinal microecological modulator, or anti-obesity drugs in the recent one month before enrollment; (5) No history of chronic gastrointestinal diseases; (6) Willingness to participate in the study and sign the informed consent form for clinical trial.
Exclusion criteria
Exclusion criteria: (1) Pregnant women, breastfeeding women, or those planning to become pregnant within the next 6 months; (2) Liver dysfunction, indicated by alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels exceeding twice the normal value; (3) Renal insufficiency, defined as a glomerular filtration rate (GFR) below 90 mL/min; (4) Hypertension, and the use of more than 2 antihypertensive drugs, with blood pressure persistently higher than 160/100 mmHg; (5) Cardiac insufficiency; (6) Anemia or other hematological disorders; (7) Inflammation or immune system diseases; (8) Diabetes; (9) Thyroid dysfunction or lactose intolerance; (10) Current smokers; These are the basic exclusion criteria, and additional conditions will be evaluated by the doctor during the screening period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Waist circumference; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total Cholesterol;Weight;Body Mass Index; | — |
Countries
China
Contacts
Public ContactGuoping Sheng
Shulan (Hangzhou) Hospital
Outcome results
None listed