Perioperative neurocognitive disorders
Conditions
Interventions
Cephalosporin Generation + Metronidazole Group:Preoperative cefazolin 1g IV with metronidazole 500mg IV. One additional intraoperative dose was given if the duration of surgery exceeded 3 hours or if
Cephalosporin III + metronidazole group:Preoperative ceftriaxone 1g IV and metronidazole 500mg IV . If the duration of surgery exceeds 3 hours or bleeding exceeds 1500 ml, an additional intraoperative
control group:No regular exercise routine
exercise group:30 minutes of exercise per day, more than 3 times per week
Sponsors
Fujian Medical University Union Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1: Age greater than or equal to 60 years 2: Those who meet the above diagnostic criteria and are proposed to undergo "combined maxillo-cervical radical surgery for oral malignant tumors" (unilateral cervical lymph node dissection). 3: Complete medical history 4: Informed consent of the patient or legal guardian or authorized delegate
Exclusion criteria
Exclusion criteria: 1: Those with severe organic brain lesions 2: Mental abnormality or cognitive impairment or history of stroke within 6 months 3: Others who are unable to complete test evaluations such as the appropriate scales 4: Intraoperative dissection of one or both internal/external jugular veins
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of cognitive functions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Structure of intestinal flora ;BDNF;C3;serum SCFA;Fecal SCFA;GDNF;Syntaxin;PSD-95; | — |
Countries
China
Contacts
Public ContactZhongmeng Lai
Fujian Medical University Union Hospital
Outcome results
None listed