central precocious puberty
Conditions
Interventions
Central Precocious Group:None
Incomplete Precocious Group:None
Control Group:None
Sponsors
Fuzhou Children's Hospital of Fujian Province
Eligibility
Sex/Gender
Female
Age
6 Years to 8 Years
Inclusion criteria
Inclusion criteria: ? Secondary sexual characteristics developed in girls before 7.5 years of age; ? Linear growth acceleration, the annual growth rate is higher than that of normal children; ? The bone age is 1 or more years older than the actual age; ? The gonads increased, pelvic B-ultrasound showed that the volume of uterus and ovary increased, and multiple follicles with a diameter of > 4mm could be seen in the ovaries; ? The hypothalamic-pituitary gonadal axis is activated, and the serum gonadotropin and sex hormone reach adolescent levels.
Exclusion criteria
Exclusion criteria: ? Obesity, hypothalamic-pituitary congenital malformations, tumors, McCune Albright syndrome, infections, invasive and inflammatory diseases, and iatrogenic or traumatic injuries; ? Other types of abnormal growth and development, including Turner syndrome, hypothyroidism, etc. ? Previous or current use of other drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biomarker; | — |
Secondary
| Measure | Time frame |
|---|---|
| Luteinizing hormone;Follicle-stimulating hormone;Bone age;Uterine volume; | — |
Countries
China
Contacts
Public ContactRuimin Chen
Fuzhou Children's Hospital of Fujian Province
Outcome results
None listed