peritoneal dialysis–associated peritonitis
Conditions
Interventions
Index test:targeted next generation sequencing, tNGS
Gold Standard:conventional microbial cultivation method
Sponsors
West China Hospital of Sichuan University, Chengdu, China
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Age = 18 years. (2) According to the diagnostic criteria outlined in the ISPD guidelines for peritoneal dialysis-associated peritonitis [1]: (? Abdominal pain and/or turbid effluent, with or without fever; ? Peritoneal fluid analysis showing white blood cell count > 100/µL and/or > 50% polymorphonuclear cells), patients suspected of having peritoneal dialysis-associated peritonitis. (3) Patients willing to undergo tNGS testing at their own expense.
Exclusion criteria
Exclusion criteria: (1) Patients who decline participation in the study or refuse to sign the informed consent form. (2) Patients with concomitant malignant tumors in the abdominal cavity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Negative cultivation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pharmacological sensitivity results or drug-resistant genes;The peritoneal dialysate white cell counts on days 1, 3, and 5; | — |
Countries
China
Contacts
Public ContactZi Li
West China Hospital of Sichuan University, Chengdu, China
Outcome results
None listed