Application of Unilateral modified-thoracoabdominal nerve block through a perichondrial approach (M-TAPA) for the perioperative analgesia in patients who underwent open liver resection

Application of unilateral modified-thoracoabdominal nerve block through a perichondrial approach (M-TAPA) for the perioperative analgesia in patients who underwent open liver resection: a prospective, randomized, double-blind, parallel-group, placebo-controlled study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300078923

Enrollment

Unknown

Registered

2023-12-21

Start date

2023-12-29

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

perioperative analgesia

Interventions

treatment group:30ml 0.375% ropivacaine unilateral modified-thoracoabdominal nerve block

control group :30ml 0.9% saline unilateral modified-thoracoabdominal nerve block

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 18-75 years old, ASA grade I-III, BMI < 35,open liver resection, Child-Pugh class A or B.

Exclusion criteria

Exclusion criteria: 1) No ability to sign informed consent, unable to communicate 2) Coagulation dysfunction 3) Allergic to ropivacaine 4) History of upper abdominal surgery or trauma. 5) Alcohol and Drug Abusers 6) Intraoperative Blood Loss > 500ml 7) Tracheal tube could not be removed for clinical reasons

Design outcomes

Primary

Measure	Time frame
Consumption of opioid analgesics;	—

Secondary

Measure	Time frame
pain score;Quality of Recovery;Consumption of vasoactive drugs;	—

Countries

China

Contacts

Public ContactJun Zhang

Fudan university Shanghai Cancer Center

snapzhang@aliyun.com+86 138 1715 3025

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026