spinal tuberculosis
Conditions
Interventions
non-sclerotic group:No
fragmentary sclerotic bone group:No
localized sclerotic margins group:No
multi-focus sclerotic margins group:No
subperiosteal group:No
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: a. Patients diagnosed with spinal tuberculosis in the outpatient department and scheduled for surgical treatment. b. This admission is the first time for anti-tuberculosis chemotherapy. c. Age between 18 to 70 years old d. ASA degree :I-III e. 18 < Body mass index (BMI, Kg/m2) < 30. Volunteer to participate in this study and sign the informed consent
Exclusion criteria
Exclusion criteria: a. Drug-resistant tuberculosis b. Patients with a history of spinal surgery or other spinal diseases. c. Patients with severe functional impairment of heart, liver, brain, lung, kidney and other important organs. d. Pregnant or lactating women, or persons with serious mental illness e. Patients with diabetes whose blood glucose control is not up to standard (fasting blood glucose >11.1mmol/L, glycosylated hemoglobin >8.0%) or with complications of diabetes. a. Patients with uncontrolled hypertension (systolic blood pressure =160mmHg, diastolic blood pressure >90mmHg), or hypotension (resting sitting blood pressure <90/50 MMHG).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| isoniazid blood concentration;isoniazid health bone tissue concentration;isoniazid focus tissue concentration;rifampin blood concentration;rifampin health bone tissue concentration;rifampin focus tissue concentration;pyrazinamide blood concentration;pyrazinamide health bone tissue concentration;pyrazinamide focus tissue concentration;ethambutol blood concentration;ethambutol health bone tissue concentration;ethambutol focus tissue concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| C reactive protein;erythrocyte sedimentation rate; | — |
Countries
China
Contacts
Public ContactZhenming Hu
Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed