Gynecological diseases (uterus, fibroids, ovaries, tubectomy, etc.)
Conditions
Interventions
Haloperidol group:Thirty minutes before the end of surgery, the 1.25 mg of haloperidol was diluted to 5 ml with saline and injected slowly intravenously.
Saline group:Thirty minutes before the end of surgery, 5 ml of saline was injected slowly intravenously.
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: ? Gynecological patients aged 18-64 years old; ? ASA classification I to III; ? Normal preoperative communication; ? Post-operative ICU admission is not expected; ? Intended to undergo laparoscopic surgery and the duration of surgery > 0.5h; ? Agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: ?.Severe respiratory and circulatory diseases: e.g. severe coronary heart disease, chronic obstructive pulmonary disease, etc. ?. Allergy to haloperidol. ?.Patients with QTc>500ms on ECG. ?.Severe endocrine system diseases: pituitary tumor, severe diabetes mellitus, etc. ?.Psychiatric disorders: schizophrenia, depression, epilepsy, history of chronic analgesic drugs, alcoholism, opioid dependents, etc. ?.Those who cannot cooperate with the study for any reason: hearing or visual impairment, language comprehension disorders, and those who cannot understand the contents of the QOR-15 scale. ?.Parkinson's disease, history of cerebral infarction, Alzheimer's disease, insomnia, severe hepatic insufficiency (ChildC), renal insufficiency (preoperative dialysis). pre-dialysis) ?. Preoperative life can not take care of themselves. ?. Inability to use intravenous analgesic pump after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score at 24 hours postoperatively.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wake-up time in the PACU;Post-operative RASS score;Length of stay at PACU;NRS scores at 6h, 12h, 24h and 48h after surgery.;QoR-15 scores on postoperative days 3 and 5.;Sleep scores (AIS) and PONV for the period of the first 3 postoperative days.;The use of opioids and remedial antiemetic drugs;Total length of hospital stay; | — |
Countries
China
Contacts
Public ContactXuesheng Liu
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed