The Impact of Frailty on Calculated Propofol Conduction and Anesthetic Depth for Inducing Loss of Consciousness in Elderly Patients

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300078888

Enrollment

Unknown

Registered

2023-12-20

Start date

2024-01-01

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Frailty

Interventions

Frailty group:None

Non-Frailty group:None

Eligibility

Sex/Gender

All

Age

65 Years to 100 Years

Inclusion criteria

Inclusion criteria: ? Aged 65 years and over ? American Society of Anesthesiologists (ASA) I-III level ? Scheduled for surgery under general anesthesia

Exclusion criteria

Exclusion criteria: ? BMI=30kg/m2 ? Allergic to propofol or its lipid emulsion ? Undergoing general anesthesia 7 days before surgery ? Severe hepatic or renal diseases ? History of severe nervous system diseases and mental illness ? History of drug or alcohol dependence

Design outcomes

Primary

Measure	Time frame
TCI calculated propofol plasma concentration;TCI calculated propofol Effect-site concentration;Bispectral index;	—

Secondary

Measure	Time frame
Propofol Requirement;Time of Loss of consciousness;Suppression Ratio;Incidence of Postoperative Delirium;	—

Countries

China

Contacts

Public ContactWeidong Gu

Department of Anesthesiology, Huadong Hospital, Fudan University

hdmz0800@163.com+86 189 1816 9021

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026