None listed
Conditions
Interventions
Group G:Glycopyrronium 4ug/kg was administered intravenouslyup G
Group W:Penehyclidine hydrochloride 10ug/kg was administered intravenously
Sponsors
The Second Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: The age ranged from 65 to 85 years. b. Undergoing total hip replacement within 3 hours; C. Asa grade I-III; d. Patients volunteered to take the test and signed the informed consent; e. No use of free depressant drugs before surgery; f. No obvious abnormality of liver and kidney function; g. no myocardial infarction in the last 3 months; h. no endocrine system disease; j. Body-mass index (BMI) of 18-25.
Exclusion criteria
Exclusion criteria: a. Diseases that may affect postoperative cognitive function; b. excessive obesity; c. Allergy to anticholinergic drugs; d. severe visual or hearing impairment; Inability to communicate effectively with a psychologist; Or unable to complete the neuropsychological test due to educational background; e. poor preoperative pulmonary oxygenation; Patients with pulse oxygen < 90% and inhaled pure oxygen < 95%; f The total score of preoperative mini-mental state Examination was less than 24; g. Patients diagnosed with sleep quality disorders before surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measures OF COGNITIVE FUNCTION;Measurement of S100A12, IL-6, and TNF-a;Sleep QUALITY MONITORING;Duration of stay in the resuscitation room; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs ;time of operation;Duration of anesthesia;Recovery time of spontaneous breathing;Time of tracheal tube removal; | — |
Countries
China
Contacts
Public ContactShi Wenyan
The Second Affiliated Hospital of Zunyi Medical University
Outcome results
None listed