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Efficacy and safety of bone wax application at different time points during total knee arthroplasty to reduce postoperative blood loss: a prospective randomized controlled trial

Efficacy and safety of bone wax application at different time points during total knee arthroplasty to reduce postoperative blood loss: a prospective randomized controlled trial

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300078822
Enrollment
Unknown
Registered
2023-12-19
Start date
2024-01-01
Completion date
Unknown
Last updated
2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

Group A:The residual femoral pulp was blocked with bone wax on the basis of autogenous osteotomy block during the operation, and the exposed cancellous bone surface around the femoral and tibial prost
Group B:The residual femoral pulp was blocked with bone wax only on the basis of filling the femoral pulp cavity with autogenous osteotomy block.
Group C:Apply bone wax to the exposed cancellous bone surfaces around the femoral and tibial prosthesis and seal the nail holes only after fixation of the prosthesis
Group D:No bone wax was used

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: (1) All patients diagnosed with osteoarthritis (OA) and undergoing primary unilateral total knee arthroplasty; (2) age 18-80 years; (3) preoperative American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) of grade I-III

Exclusion criteria

Exclusion criteria: (1) preoperative anemia or blood system diseases, baseline hemoglobin lower than 11 g/dL; (2) long-term use of anticoagulants; (3) preoperative lower limb vascular disease; (4) poor compliance; (5) high-risk medical comorbidities (liver and kidney function diseases); (6) revision surgery; (7) history of major knee surgery.

Design outcomes

Primary

MeasureTime frame
Total blood loss;Blood transfusion rate;

Secondary

MeasureTime frame
occult blood loss;Intraoperative blood loss;Incidence of postoperative complications;Indicator of inflammation level;Visual analogue scale pain score;Range of knee motion;Lower Limb Diameter (Perimeter of the Patellar);

Countries

China

Contacts

Public ContactKang Pengde

West China Hospital, Sichuan University

724339027@qq.com+86 139 5422 6812

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026