ARDS
Conditions
Interventions
Control group:standard treatment
intervention group:place an esophageal pressure monitoring tube and set ventilator parameters based on monitoring values
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (i)Age =18 years; (ii) Received invasive mechanical ventilation for no more than 48 h and expected duration of mechanical ventilation for more than 72 h at the time of inclusion. (iii) PaO2/FiO2 =150 mmHg.
Exclusion criteria
Exclusion criteria: Time of invasive mechanical ventilation before transferring to ICU>48h; ?pregnant women; ?patients who are not suitable for the placement of esophageal pressure monitoring tube; ?refuse to be enrolled in the study; ?end-stage patients; ?patients with neuromuscular blocking disease, severe central nervous system pathology; ?patients who are under other studies; ?combined with COPD or ILD and other chronic lung diseases; ?serious coagulation dysfunction; ?pneumothorax, esophago-tracheal Fistula, esophageal tracheal fistula, tracheomediastinal fistula, etc.; ? receiving ECMO treatment; ? hematologic disease, liver and kidney transplantation, bone marrow transplantation, severe cardiac disease, hemodynamic instability, and other conditions that are not suitable for inclusion in the study in the opinion of the clinician-investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ventilator-free days at 28 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Diaphragm thickening fraction;LOS in ICU;ICU morbidity and mortality; | — |
Countries
CHINA
Contacts
Public ContactShen Feng
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed