Laparoscopic bariatric surgery
Conditions
Interventions
Intervention group(MOSA group):Administering the modified opioid sparing anesthesia (MOSA) to patients: Intravenous pump dexmedetomidine 0.5ug/kg, after 10 minutes of pumping, Anesthesia was induced b
Control group(OBA group):Opioid based anesthesia (OBA) will be induced by intravenous injection of midazolam 2mg, dexamethasone 0.1mg/kg, propofol 1.5-2.5 mg/kg, sufentanil 0.4ug/kg and vecuronium 0.1
Sponsors
Yan 'an Hospital of Kunming City
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1Adult (18 years or older) patients admitted to this study. 2Undergoing a scheduled laparoscopic bariatric surgery[Roux-en-Y gastric bypass(LRYGB) and sleeve gastrectomy(SG)]. 3ASA class ?-?. 4Having signed an informed consent.
Exclusion criteria
Exclusion criteria: 1. Current pregnancy or breastfeeding. 2. Patients with contraindications or allergies to the use of drugs such as esketamine, dexmedetomidine and lidocaine. 3. Severe mental illness such as schizophrenia, depression and dementia. 4. History of abuse of alcohol, opioids or other psychotropic drugs. 5. Patients unable to cooperate with the study for any reason, such as language comprehension disorder, hearing impairment or mental illness. 6. Preoperative planned intensive care unit (ICU) admission. 7. Individuals already participating in other studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the quality of postoperative recovery according to the QoR-15 questionnaire scores on postoperative day 1 (POD1); | — |
Secondary
| Measure | Time frame |
|---|---|
| The QoR-15 score on postoperative day 2 (POD2).;The amount of drinking water of patients in 24h and 48h, the time to first flatus,and first defecation;Postoperative patient comfort and satisfaction in 24h,48h after surgery;Postoperative pain intensity on the NRS values in 24h,48h after surgery;The incidence and severity of postoperative nausea and vomiting (PONV);Intraoperative and postoperative opioid consumption (morphine equivalent);The anxiety and depression status of patients ;Length of hospital stay;Blood gas analysis was performed preoperatively, intraoperatively and postoperatively; | — |
Countries
China
Contacts
Public ContactLi Shikuo
Yan 'an Hospital of Kunming City
Outcome results
None listed