infections due to extensively drug-resistant Gram-negative bacteria
Conditions
Interventions
Sponsors
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) patients with the documented extensively drug-resistant Gram-negative bacteria (XDR-GNB) infections including Pseudomonas aeruginosa and Enterobacteriaceae; (2) patients received intravenous ceftazidime/avibactam or intravenous polymyxin B as the initial treatment for more than 2 days; (3) age=18 years.
Exclusion criteria
Exclusion criteria: (1) pregnancy or lactation; (2) incomplete clinical data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| all-cause mortality at 28 day; | — |
Secondary
| Measure | Time frame |
|---|---|
| all-cause mortality at 14 day;proportion of patients with bacterial eradication at 14 day;proportion of patients with clinical response at 14 day;Iincidence of acute kidney injury;hospital length of stay;days of antibiotics-free within 28 days;days of mechanical ventilation within 28 days;days of renal replacement therapy within 28 days;days with vasopressors within 28days; | — |
Countries
China
Contacts
Public ContactJuan Zeng
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed