Sepsis
Conditions
Interventions
Normal myocardial microcirculation (N) group:None
Myocardial microcirculation disorders (D) group:None
Using the Esmolol (E) group:None
Unused Esmolol (C) group:None
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) age >18 years and <80 years; (2) fulfillment of diagnostic criteria (increased cardiac enzymology indexes, LVEF <50%, or LVEF =50% and LVEDD <50 mm, and exclusion of acute myocardial infarction); (3) voluntary signing of an informed consent for enrollment.
Exclusion criteria
Exclusion criteria: ?Severe heart diseases such as valve disease, myocarditis, cardiomyopathy, myocardial infarction, etc.;?Severe cardiac insufficiency: LVEF<20% or cardiac function level IV;?ICU hospitalization time<48 hours;?Refusing to accept PET or contrast-enhanced ultrasound examination;?Sinus bradycardia, degree II and III atrioventricular block, sick sinoatrial node syndrome;?Known effects on Esmolol or others ß Receptor blocker allergy;?Severe liver and kidney dysfunction and electrolyte disorders;?Pregnancy or preparation status or lactation period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial contrast echocardiography myocardial perfusion parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac function indicators;Use of vasoactive drugs;Myocardial microcirculation indicators;Cardiovascular events during hospitalization;Hemodynamic indicators;Peripheral microcirculation perfusion and metabolic status; | — |
Countries
China
Contacts
Public ContactLiu Wenhua
The Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed