borderline high blood cholesterol
Conditions
Interventions
Placebo control group:Placebo (3.3g/d starch)
Phytosterol intervention group:Phytosterol (2.0g/d) and starch (1.3g/d)
Phytosterol and phospholipid intervention group:Phytosterol (2.0g/d) and phospholipid (0.825g/d) and starch (0.475g/d)
Sponsors
Qingdao University
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age ranging from 30 to 65, with no limit on gender or ethnic group; (2) BMI = 24kg/m²; (3) Raised blood lipid margin: it can meet any of the following conditions. Mild hypercholesterolemia: serum 5.2 mmol/L = TC < 6.2 mmol/L or 3.4 mmol/L = LDL-C < 4.1 mmol / L; Mild hypertriglyceridemia: 1.7 mmol/L = TG <2.3 mmol/L; Mild mixed hyperlipidemia: 1.7 mmol/L = TG <2.3mmol / L, and at least one of the following conditions: 5.2 mmol/L = TC <6.2mmol/L,3.4mmol/L = LDL-C < 4.1mmol / L. (4) Patients with good control of chronic diseases such as diabetes and hypertension, and no serious liver, kidney, thyroid, cardiovascular, cerebrovascular, digestive system and other diseases; (5) Did not use any related drugs (such as diuretics, ß receptor blockers, statins or other drugs), and nutritional supplements rich in phytosterols and phospholipids in the past 3 months; (6) Voluntary participation in this study, and signed an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with infectious diseases, malignant tumors and mental illness; (2) Allergic constitution and allergy to the ingredients of the test products; (3) Excessive smoking or alcoholism [excessive smoking (= 2 packs / day, = 10 years of smoking age), alcoholism (> 70 g / day for men,> 56 g / day for women); (50ml is equivalent to 1 two) 70g of alcohol is equivalent to 1,700 ml of beer, 750ml of wine and 38° of 250ml of liquor 56g of alcohol is equivalent to 1400ml of beer, 600ml of wine and 38° of 170ml of liquor; Alcohol intake (grams) = alcohol intake (ml) multiply alcohol intake (%) multiply 0.8 (4) Special dietary habits: vegetarians, weight managers, ketogenic diet (high fat, low carbohydrate), etc.; (5) pregnant or lactating women; (6) Unable to follow the trial requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Five indice of blood lipid;Oxidative stress index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythrocyte membrane fluidity and lipid detection;Fecal sterol and lipid content;Fecal fat content;routine blood test;blood sugar;Liver function index;kidney function index; | — |
Countries
China
Contacts
Public ContactJing Cai
Qingdao University
Outcome results
None listed