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Experimental and clinical study on the regeneration of new blood vessels and epithelium by scar transplantation technique of retaining perforated edge of tympanic membrane

Experimental and clinical study on the regeneration of new blood vessels and epithelium by scar transplantation technique of retaining perforated edge of tympanic membrane

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300078776
Enrollment
Unknown
Registered
2023-12-18
Start date
2023-12-25
Completion date
Unknown
Last updated
2025-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic tympanic membrane perforation

Interventions

Experimental group:The scar tissue of the perforated margin and the epithelium of the exposed malleus manubrium were preserved and endochondroperichondrium endoplasty was performed. Intraoperative ear
Control group:Endoscopic chondroperichonioplasty was performed after the scar tissue of the perforated margin was removed and the epithelium of the exposed malleus manubrium was removed. Intraoperativ

Sponsors

Yiwu Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: [1] Chronic perforation in adults with an area of 1/4-1/2 tension and dry ear for at least 3 months; [2] At least 0.5mm perforated edge; [3] No ossicular chain lesions or middle ear cholesteatoma; [4] Endoscopy showed no perforated marginal epithelium growing inwardly over the tympanic cavity; [5] Preoperative high resolution CT of temporal bone indicated that the air chamber of the middle ear mastoid was well pneumatized.

Exclusion criteria

Exclusion criteria: [1] With fungal otitis extern; [2] Suspected ossicular chain disease or middle ear cholesteatoma;

Design outcomes

Primary

MeasureTime frame
Graft success rate;hearing improvement;

Secondary

MeasureTime frame
middle ear cholesteatoma;

Countries

China

Contacts

Public ContactZhengcai Lou

Yiwu Central Hospital

louzhengcai@163.com+86 137 3899 6868

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026