Crohn's disease
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Age= 18 years old; 2) The diagnosis of CD is in line with the 2018 "Consensus Opinion on the Diagnosis and Treatment of Inflammatory Bowel Disease"; 3) Patients with moderate to severe active CD (CDAI=220). 4) Use ustekinumab for induction therapy and/or maintenance therapy.
Exclusion criteria
Exclusion criteria: a) contraindications to ustekinumab; b) diagnosed with ulcerative colitis (UC) or indeterminate colitis (IC) or IBDU; c) any type of bowel resection or other abdominal surgery within the past 3 months, or a history of > 3 previous bowel resections; d) Severe intestinal strictures, toxic megacolon or explosive enteritis, which may require surgery during the visit; e) history of cancer; f) In a state of severe infection (combined clinical, doctor's judgment). g) Baseline bowel wall thickness (BWT) is normal for all bowel segments (terminal ileum= 2.0 mm, colonic = 3.0 mm)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive protein;Fecal calprotectin;Blood routine;Blood biochemistry;ESR;Transmural healing evaluated by endoscopic ultrasound; | — |
Secondary
| Measure | Time frame |
|---|---|
| T-SPOT; | — |
Countries
China
Contacts
Public ContactWei Han
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed