depression
Conditions
Interventions
SAINT group:Stimulation target: the area within the DLPFC with the most negative brain functional connectivity with the the subgenular anterior cingulate cortex (sgACC). Treatment parameters: iTBS mod
Sponsors
West China Xiamen Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: ? Age between 18–60 years; ? Right-hand dominant; ? Diagnosed with MDD according to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorder (DSM-5); ? Hamilton Rating Scale for Depression-17 item (HAMD-17) total score more than 18; ? Maintain a stable dose of antidepressant medication treatment for at least 4 weeks before enrollment, and unchanged throughout the entire study period; ? Volunteer to participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: ? Physical diseases: endocrine system diseases such as hyperthyroidism, hypothyroidism or diabetes; ? Organic brain diseases: birth injury, trauma, encephalitis, tumors, etc Peripheral nerve and muscle system lesions; ? Suffering from other mental illnesses such as schizophrenia and obsessive-compulsive disorder; ? Have a history of mania or hypomania in the past; ? Recently taken drugs that may cause emotional disorders, such as Levofloxacin; ? History of alcohol abuse or psychoactive substance abuse; ? Pregnant or lactating women There are contraindications to the use of TMS, such as a history of epilepsy or individuals with intracranial metal implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the score of HAMD-17; | — |
Secondary
| Measure | Time frame |
|---|---|
| the score of HAMA;the score of MARDS;the score of C-SSRS;the score of CGI-S;the score of PSQI;the score of BDI-II; | — |
Countries
China
Contacts
Public ContactZheng Zhong
West China Xiamen Hospital of Sichuan University
Outcome results
None listed