IgG4-related Kidney Disease (IgG4RKD)
Conditions
Interventions
1:Sirolimus 1mg/ day (Initial dose),target trough concentration 5-8µg/L
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-80 years old; male (2) IgG4-RKD patients diagnosed by renal biopsy pathology, and regularly followed-up rin our hospital; (3) The patient has completed induced remission therapy and entered the maintenance treatment stage; (4) Prednisone dose =<15mg/d (or equivalent of other glucocorticoids), other immunosuppressant doses stable for more than 4 weeks; (5) The patient or family member is able to understand the study protocol and is willing to participate in the study, providing written informed consent.
Exclusion criteria
Exclusion criteria: (1) The presence of metal in the body ; (2) Combined with IgG4-RD mimic diseases, such as vasculitis, hematological malignancy, etc.; (3) Have a birth plan in the near future (4) Obvious abnormal liver function; (5) Being in the state of kidney dialysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eGFR; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum IgG4;urine protein;renal MRI parameter-K value;renal MRI parameter-ADC value; | — |
Countries
China
Contacts
Public ContactKe Zheng
Peking Union Medical College Hospital
Outcome results
None listed