Effects and mechanism of bupivacaine liposomal brachial plexus block on ischemia and reperfusion injury in limb treated by digital replantation

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300078728

Enrollment

Unknown

Registered

2023-12-17

Start date

2023-12-17

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Replantation of severed fingers

Interventions

Control group:Ropivacaine Hydrochloride Injection

experimental group:Bupivacaine liposomes

Eligibility

Sex/Gender

All

Age

16 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) Emergency patients undergoing amputated finger replantation; (2) Age =16 years old, male or female; (3) American Society of Anesthesiologists (ASA) grade ?~?

Exclusion criteria

Exclusion criteria: Exclusion criteria: (1) allergic to the local anesthetics ropivacaine and bupivacaine or their drug components; (2) a history of renault's syndrome ;(3) patients during pregnancy or lactation; (4) who underwent autogenous vascular transplantation due to the absence or necrosis of intrinsic vessels caused by crush or avulsion injury; (5) contraindication of brachial plexus block or disagreement with brachial plexus block; (6) cognitive impairment or inability to communicate effectively; (7) who were deemed unsuitable for the trial by the investigators.

Design outcomes

Primary

Measure	Time frame
eplantation refers to the incidence of vascular embolism;	—

Secondary

Measure	Time frame
After surgery, 12h, 24h, 36h, 48h, and 3 days after surgery until discharge, the skin temperature difference and tissue perfusion scores of the reimplanted fingers were recorded;During hospitalization, adverse events such as postoperative finger vasospasm, vascular embolism, vascular crisis, secondary surgical exploration, and finger body necrosis occurred;The success rate of replantation of severed fingers;Preoperative and postoperative 2 h, 12 h, 1 d and 2 d, 3 d, 4 d numerical rating scale (NRS) and cumulative pain score calculation;Proportion of patients receiving rescue pain medication within 72 hours after surgery;Total use of rescue analgesics within 72 hours after surgery;Preoperative and postoperative 1 d, 3 d, 5 d Malondialdehyde peroxide (MDA), tumor necrosis factor a (TNF - a), interleukin - 18 (IL - 18), pain substance (SP), dopamine (DA) levels;	—

Measure

Time frame

After surgery, 12h, 24h, 36h, 48h, and 3 days after surgery until discharge, the skin temperature difference and tissue perfusion scores of the reimplanted fingers were recorded;During hospitalization, adverse events such as postoperative finger vasospasm, vascular embolism, vascular crisis, secondary surgical exploration, and finger body necrosis occurred;The success rate of replantation of severed fingers;Preoperative and postoperative 2 h, 12 h, 1 d and 2 d, 3 d, 4 d numerical rating scale (NRS) and cumulative pain score calculation;Proportion of patients receiving rescue pain medication within 72 hours after surgery;Total use of rescue analgesics within 72 hours after surgery;Preoperative and postoperative 1 d, 3 d, 5 d Malondialdehyde peroxide (MDA), tumor necrosis factor a (TNF - a), interleukin - 18 (IL - 18), pain substance (SP), dopamine (DA) levels;

—

Countries

China

Contacts

Public ContactShucong Liang

the Third Affiliated Hospital of Guangxi Medical University

huangyanjuan66@163.com+86 771 480 8259

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026