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Exploratory study on the effect of intraperitoneal perfusion of drug-loaded vesicles on the peritoneal immune microenvironment after radical resection of hepatobiliary carcinoma

Exploratory study on the effect of intraperitoneal perfusion of drug-loaded vesicles on the peritoneal immune microenvironment after radical resection of hepatobiliary carcinoma

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300078719
Enrollment
Unknown
Registered
2023-12-15
Start date
2023-12-15
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatobiliary system cancer

Interventions

Sponsors

Tianjin Third Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 75 Years

Inclusion criteria

Inclusion criteria: ? between 40 and 75 years old; ? Primary liver cancer or cholangiocarcinoma that meets the clinical diagnostic criteria of NCCN Guidelines Version 2.202 or is confirmed by histopathology or cytology; (3) Meet the indication of radical resection (restricted to open surgery); ? Child-Pugh liver function grade A or B; ? ECOG-PS score 0-1; ? Expected survival =6 months; ? Subjects voluntarily participate and sign informed consent.

Exclusion criteria

Exclusion criteria: Patients with any of the following conditions are not allowed to enter or continue the study: ? Have a history of immunosuppressive drugs or a history of immune deficiency; ? Have seen other clinical experimenters in the last three months; ? Patients with previous malignant tumors <5 years; ? Patients who have received other surgical treatment for less than 6 months; (5) Women who are breastfeeding, pregnant or planning to become pregnant; ? Patients who are known to be allergic to test sample components or their analogues; 7 Patients with contraindications to abdominal perfusion; 8 Patients with cognitive impairment or poor treatment compliance determined by researchers; Other severe, acute, or chronic medical conditions that may interfere with the findings; ? Other conditions deemed unsuitable for inclusion or inappropriate for clinical trials by the investigator

Design outcomes

Primary

MeasureTime frame
Immune cell subsets;

Secondary

MeasureTime frame
Average length of stay;Postoperative complication;

Countries

China

Contacts

Public ContactWang Ximo

Tianjin Third Central Hospital

wangximo@126.com+86 186 9808 7123

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026