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An exploratory study of the effect of peritoneal infusion of drug-loaded vesicles on peritoneal immune microenvironment after radical resection of colorectal cancer

An exploratory study of the effect of peritoneal infusion of drug-loaded vesicles on peritoneal immune microenvironment after radical resection of colorectal cancer

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300078718
Enrollment
Unknown
Registered
2023-12-15
Start date
2023-12-15
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

Sponsors

Tianjin Third Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 75 Years

Inclusion criteria

Inclusion criteria: ? between 40 and 75 years old; ? Patients diagnosed with colon cancer, rectal cancer or colon cancer combined with rectal cancer by total colorectal colonoscopy and histopathological biopsy, and who received elective laparoscopic radical resection of colorectal cancer for the first time; ? Meet the indication of radical resection (limited to laparoscopic surgery); ?ECOG-PS score 0-1; (5) Expected survival =6 months; ? Subjects voluntarily participate and sign informed consent.

Exclusion criteria

Exclusion criteria: Patients with any of the following conditions are not allowed to enter or continue the study: ? Have a history of immunosuppressive drugs or a history of immune deficiency; ? Have seen other clinical experimenters in the last three months; ? Patients with previous malignant tumors <5 years; ? Patients who have received other surgical treatment for less than 6 months; (5) Women who are breastfeeding, pregnant or planning to become pregnant; ? Patients who are known to be allergic to test sample components or their analogues; 7 Patients with contraindications to abdominal perfusion; 8 Patients with cognitive impairment or poor treatment compliance determined by researchers; Other severe, acute, or chronic medical conditions that may interfere with the findings; ? Other conditions deemed unsuitable for inclusion or inappropriate for clinical experimenter by the investigator.

Design outcomes

Primary

MeasureTime frame
Immune cell subsets;Postoperative complication;

Secondary

MeasureTime frame
Average length of stay;

Countries

China

Contacts

Public ContactWang Ximo

Tianjin Third Central Hospital

wangximo@126.com+86 186 9808 7123

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026