COVID-19
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.18-85 years old (including 18 and 85 years old), regardless of gender. 2.The subjects tested positive for SARS-CoV-2 nucleic acid in sputum / nasal swabs / pharyngeal swabs / lower respiratory tract secretions before hospitalization, or positive for throat swab antigens during COVID-19 epidemic. Diagnosed with novel coronavirus infection. 3. The patient meets the diagnostic criteria of common(moderate) COVID-19 in the latest version of COVID-19 Diagnosis and Treatment Plan (9th Edition) issued by the China Health Commission. 4. After three to seven days of oral treatment with azivudine or nimatevir/ritonavir, the chest CT showed that the lesions of pneumonia increased or enlarged. 5. There is at least one possible risk factor for severe / critical disease: (1) age > 60 years old; (2) basic diseases such as cardio-cerebrovascular disease (including hypertension), chronic pulmonary disease (chronic obstructive pulmonary disease), diabetes, chronic liver disease, chronic kidney disease, tumor, etc. (3) immune deficiency (such as AIDS patients, decreased immune function caused by long-term use of corticosteroids or other immunosuppressive drugs); (4) obesity (body mass index = 30kg/m^2); (5) heavy smokers; (6) those who have not been vaccinated with new crown vaccine. 6. Understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe COVID-19 patients meet any of the following criteria:(1) shortness of breath, respiratory rate =30/min;(2) in resting state, oxygen saturation (SpO2) = 93% when inhaling air;(3) arterial oxygen partial pressure PaO2/ inhaled oxygen concentration (FiO2) = 300mmHg;(4) the clinical symptoms worsened progressively, and pulmonary imaging showed that the lesion progressed more than 50% within 24-48 hours. 2.Critical COVID-19 patients meet any of the following criteria:(1) respiratory failure and need mechanical ventilation;(2) shock;(3) ICU monitoring and treatment for patients with other organ failure. 3. Hyperallergenic constitution, including allergic bronchial asthma, etc. 4. Suspected or confirmed presence of bacteria, fungi, atypical pathogens and other pathogens in the lungs. 5. Pregnant or lactating women or those with positive pregnancy test, or those who plan to conceive within half a year. 6. The researchers believe that other factors that are not suitable for entering the trial, such as difficulties in communication, severe neurological and mental disorders, and severe physical weakness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement rate of chest imaging on the 5th day; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of negative SARS-CoV-2 nucleic acid test;Quantitative score of symptoms (shortness of breath, cough, expectoration), signs;Oxygenation index, inflammatory factors, blood routine;The rate of common(moderate) COVID-19 aggravating to severe COVID-19; | — |
Countries
China
Contacts
Public ContactLiqiang Song
The First Affiliated Hospital of the Air Force Military Medical University
Outcome results
None listed