COVID-19
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.18-85years old (including18and85years old), regardless of gender. 2.COVID-19-related symptoms such as fever and cough occurred within 2 weeks of onset. 3.After the onset of the disease, the subjects were positive for SARS-CoV-2 nucleic acid or antigen in sputum / nasal swabs / pharynx swabs / lower respiratory tract secretions. Diagnosed as COVID-19. 4. Meet the diagnostic criteria of moderate and severe patients in the latest version of COVID-19 Diagnosis and Treatment Program (10th Edition) issued by the China Health Commission. 5. Did not receive antiviral treatment before entering the group. 6. Understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Critical COVID-19 patients meet any of the following criteria:(1) respiratory failure and need mechanical ventilation;(2) shock;(3) ICU monitoring and treatment for patients with other organ failure. 2.Hyperallergenic constitution, including allergic bronchial asthma, etc. 3.Suspected or confirmed presence of bacteria, fungi, atypical pathogens and other pathogens in the lungs. 4.Pregnant or lactating women or those with positive pregnancy test, or those who plan to conceive within half a year. 5.There are basic pulmonary diseases that significantly affect the observation of pulmonary imaging (such as bronchiectasis, interstitial lung disease, pneumoconiosis). 6. The researchers believe that other factors that are not suitable for entering the trial, such as difficulties in communication, severe neurological and mental disorders, and severe physical weakness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement rate of chest imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of negative SARS-CoV-2 nucleic acid test or Ct value;Quantitative score of symptoms (fatigue, shortness of breath, cough, expectoration),signs;Inflammatory factors, blood routine;The rate of aggravation of COVID-19 clinical classification(moderate aggravated to severe,severe aggravated to critical); | — |
Countries
China
Contacts
Public ContactLiqiang Song
The First Affiliated Hospital of the Air Force Military Medical University
Outcome results
None listed