Tuberculosis
Conditions
Interventions
Gold Standard:Cultivation of mycobacterium tuberculosis
Index test:Sputum or bronchoalveolar lavage fluid samples were collected from adult suspected PTB patients, and the performance of smear, culture, XpertMTB/RIF, mNGS, tNGS and Nanopore in the detectio
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) tuberculosis related clinical symptoms (such as cough, fever, night sweats) and imaging changes (for example, granuloma and cavity), gamma interferon release test positive as suspected PTB cases into the group. 2) at least 18 years old. 3) past, who was not involved in other clinical trials.
Exclusion criteria
Exclusion criteria: 1) severe disseminated tuberculosis with an expected survival of no more than 3 months as judged by the competent physician 2) during pregnancy or lactation women 3) the people with TB diagnosis (any) meet the following: a There was no evidence of tuberculosis infection b) clearly other pathogen infection c. Non-anti-tuberculosis treatment is effective
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ability to detect drug-resistance mutations in first - and second-line TB drugs;Accuracy ;Positive predicative value; | — |
Countries
China
Contacts
Public ContactHe Jianqing
West China Hospital, Sichuan University
Outcome results
None listed